NAD+ Precursor
NMN (Nicotinamide Mononucleotide)
Emerging EvidenceRecommended Dose
500–1000 mg daily
Timing
Morning on empty stomach
Mechanism of Action
Direct precursor to NAD+ via the salvage pathway. Elevates NAD+ levels to activate sirtuins (SIRT1-7) for DNA repair, mitochondrial function, and epigenetic regulation of aging pathways.
Side Effects & Safety
Generally well-tolerated in trials up to 1250 mg. Mild nausea or flushing reported. Long-term human safety data still limited. Theoretical oncology concerns debated.
Synergies
CoQ10PQQOmega-3