Adaptogen
Ashwagandha
Strong EvidenceRecommended Dose
600 mg KSM-66 or 300 mg Sensoril daily
Timing
Morning or evening with food
Mechanism of Action
Withanolides modulate the HPA axis, reducing cortisol production. Also acts as a GABAergic anxiolytic and supports thyroid hormone synthesis. Enhances DHEA-S and testosterone.
Side Effects & Safety
May cause drowsiness, mild GI upset. Avoid with thyroid medication or autoimmune conditions without medical supervision. Rare liver concerns at very high doses.
Synergies
Rhodiola RoseaMagnesium GlycinateL-Theanine