Synthetic Nootropic
Noopept
Moderate EvidenceRecommended Dose
10–30 mg daily (start at 10 mg)
Timing
Morning, sublingual or with food
Mechanism of Action
Modulates AMPA and NMDA glutamate receptors, enhancing long-term potentiation. Increases BDNF and NGF expression in the hippocampus. Up to 1000x more potent by weight than piracetam.
Side Effects & Safety
Irritability, headache, or brain fog if choline intake is insufficient. Insomnia if taken late. Not well-studied long-term. Cycle 8 weeks on, 2 weeks off.
Synergies
CiticolineAlpha-GPCLion's Mane