Botanical
Saffron (Crocus sativus)
Moderate EvidenceRecommended Dose
30 mg standardized extract daily
Timing
Morning with food
Mechanism of Action
Crocin and safranal modulate serotonin reuptake and NMDA receptor activity. Anti-inflammatory via NF-kB inhibition. Clinically comparable to low-dose SSRIs for mild-to-moderate depression.
Side Effects & Safety
Generally safe at recommended doses. High doses (>200 mg) may cause dizziness, dry mouth, or anxiety. Avoid during pregnancy. May potentiate SSRIs.
Synergies
Omega-3AshwagandhaMagnesium Glycinate