Phospholipid
Phosphatidylserine
Moderate EvidenceRecommended Dose
100–300 mg daily
Timing
Morning or evening with food
Mechanism of Action
Major component of neuronal cell membranes. Modulates membrane fluidity, neurotransmitter release (acetylcholine, dopamine), and blunts cortisol response to stress via HPA axis regulation.
Side Effects & Safety
Very well-tolerated. Rare insomnia or GI discomfort at higher doses. Modern PS is soy or sunflower-derived (not bovine).
Synergies
Omega-3Alpha-GPCBacopa Monnieri