Phospholipid
Phosphatidylserine
Moderate EvidenceSupported by trials in age-associated memory impairment, and it carries an FDA qualified health claim - which is explicitly a claim backed by limited and inconclusive evidence, not an endorsement.
Recommended Dose
100–300 mg daily
Timing
Morning or evening with food
Mechanism of Action
Major component of neuronal cell membranes. Modulates membrane fluidity, neurotransmitter release (acetylcholine, dopamine), and blunts cortisol response to stress via HPA axis regulation.
Side Effects & Safety
Very well-tolerated. Rare insomnia or GI discomfort at higher doses. Modern PS is soy or sunflower-derived (not bovine).
Do not use / talk to a doctor first
- Known allergy to the source material - modern products are soy or sunflower derived, which matters if you have a soy allergy
Interactions
Anticoagulants and antiplatelet drugs
Frequently listed as a bleeding interaction, and the evidence does not support that for oral supplements. The anticoagulant finding comes from a 1981 study of INTRAVENOUS phosphatidylserine, and in other contexts phosphatidylserine ACCELERATES coagulation. Neither describes taking a capsule. Treat this as unestablished in both directions rather than as a warning or an all-clear
Source: Tersenov 1981, Vopr Med Khim (PMID 7314577)
Pregnancy & breastfeeding
Not adequately studied in pregnancy or breastfeeding. Not recommended without medical advice.
Who should avoid / see a doctor
Anyone with a soy allergy should check the source, since most products are soy-derived. Beyond that there is no established contraindication for oral phosphatidylserine, and the bleeding warning that circulates alongside it rests on intravenous and in-vitro work rather than on supplement use.
Synergies
Used in These Stacks
See Phosphatidylserine inside a full protocol — the stack pages cover when and why to combine it.
Best Products
Partner offers
Paid placements. We earn a commission if you buy through these links, at no extra cost to you — it does not change what we write. These are the seller’s own products and claims, not ours, and nothing here is medical advice. Speak to a clinician before starting any supplement.
References
- 1.Tersenov 1981, Voprosy Meditsinskoi Khimii — Intravenous phosphatidylserine produced a dose-dependent decrease in blood coagulation activity - an intravenous finding, not a study of oral supplementation. (intravenous administration, 1981)
